Sunday, May 22, 2011

Oligosaccharide Cellulose Membrane by click chemistry for Virus Adsorption

Previously Hatanaka and coworkers demonstrated that production of oligosaccharides (sialyl lactoside derivatives) was achieved by using saccharide primers (azidododecyl beta-lactosides) and B16 cells. 

Chemistry & Biodiversity, 2005, 1063.

Now they have used click chemistry to modify carboxymethylated cellulose (CMC) with terminal alkyne functional groups and introduced oligosaccharide via triazole clcik chemistry. The membrane was shown to have adsorption ability of influenza virus. The click chemistry is shown in the drawing.

The Open Chemical and Biomedical Methods Journal 2009, 13.