Sunday, December 25, 2011

Allozyne AZ01 click chemistry in the drawing

The chemistry of AZ01 in the drawing; triazole click chemistry in purple

Allozyne AZ01 towards the first drug applying click chemistry?

Will AZ01 win the race as the “first” drug applying triazole click chemistry?

10/18/2011 Allozyne announces positive results from multiple ascending dose (MAD) Phase 1B trial of AZ01, the lead product candidate developed by Biociphering platform, for the treatment of relapsing-remitting multiple sclerosis (RRMS). AZ01 is a next-generation long-lasting interferon beta for the treatment of MS, the chronic inflammatory and degenerative brain disease. The MAD study suggested an improved tolerability profile in monthly therapy.

Allozyne Biociphering platforms enable site-specific incorporation of non-natural amino acid in the target protein, allowing further bioconjugation with a host of molecules for enhanced therapeutic properties of target proteins. Click chemistry has been powering this highly efficient conjugation.

Two versions of Biciphering platforms exist: CAESAR (E Coli based) and VIGENERE (mammalian cells based). The former has produced AZ01 (MS) and AZ17 (Crohn’s Disease) in the pipeline, while the latter has AZ05 (Oncology).

See a previous announcement on AZ01 by Allozyne 
7/15/2010 Allozyne licenses Click Chemistry from Scripps

Saturday, December 10, 2011

Click chemistry a click away

This is to respond to a reader's excellent request - why not put together a list of vendors of click chemistry reagents, with active links, to make click chemistry a click away? Here it goes:

A few notes:
1. No way it is exclusive - please let me know the ones I have missed so I can add them in future updates.
2. Chances are the addresses would change over time - the best way then is to copy the company link to your web browser and click to get to the vendor followed by search that website. 
3. It was stated why "vendors matter" in a separate post.

Sunday, December 4, 2011

Diels-Alder Click Chemistry for Tissue Engineering Hydrogel

Biomacromolecules, 2011, 12 (3), pp 824–830

Diels-Alder cycloaddition satisfies click chemistry criteria and features elegant multiple-bond formation in a single step in very high yeild. Here a furan diene was installed onto the natural polymer hyaluronic acid and it was cross-linked by a bifunctional dienophile, dimaleimide poly(ethylene glycol) to form the cytocompatible hydrogels for potential soft tissue engineering. The click reaction runs smoothly in aqueous buffer without initiator, catalyst, or other coupling reagents.