tag:blogger.com,1999:blog-7691305304533491682024-03-13T23:12:06.104-05:00Click ChemistryEverything about Click Chemistry.
Chemistry is the Central Science. Let Click Chemistry be the entry.Hongyi Wanghttp://www.blogger.com/profile/16501921836360298962noreply@blogger.comBlogger90125tag:blogger.com,1999:blog-769130530453349168.post-88113299574697689052014-01-11T15:36:00.001-06:002014-05-26T11:05:48.025-05:00Phosphate-modified nucleotides, DNA sequencing, etc<span style="font-family: Arial, Helvetica, sans-serif;">Well, in those years after 2000, the raging race was on for new DNA sequencing platforms. We know click chemistry concept came into publications around that time as well. </span><br />
<span style="font-family: Arial, Helvetica, sans-serif;"><br /></span><span style="font-family: Arial, Helvetica, sans-serif;">The earliest work combining these two came in 2008. NTPs were modified at terminal phosphates with click chemistry groups such as terminal alkene, terminal alkyne, and azide. Click chemistry was performed to generate libraries used as polymerase substrates in DNA sequencing platforms. Those were published as patent applications: </span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">WO 2009/091847 (PCT/US2009/031027); WO 2009/105077 (PCT/US2008/008612); US 2001/0165652. </span><br />
<span style="font-family: Arial, Helvetica, sans-serif;"><br /></span><span style="font-family: Arial, Helvetica, sans-serif;">In the same spirit / approach, here is the most recent piece of work:</span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">Chem Comm, 12/20/2013 <a href="http://pubs.rsc.org/en/content/articlelanding/2013/cc/c3cc48937j#!divAbstract" target="_blank">Advance Article for 2014</a>, </span><br />
<span style="font-family: Arial, Helvetica, sans-serif;">"Synthesis of r-labeled nucleotide 5'-triphosphates using click chemistry". </span><br />
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Hongyi Wanghttp://www.blogger.com/profile/16501921836360298962noreply@blogger.com0tag:blogger.com,1999:blog-769130530453349168.post-85102800422495889832013-10-13T15:02:00.000-05:002013-10-13T15:02:32.179-05:00Nobel Prize or not <span style="font-family: Arial, Helvetica, sans-serif;">Well, the 2013 Nobel Prize went to computational chemistry. </span><br />
<span style="font-family: Arial, Helvetica, sans-serif;">Entirely deserving.</span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">The prediction of Click Chemistry in the race settles.</span><br />
<span style="font-family: Arial, Helvetica, sans-serif;">Probably too much prediction going on in this "tricky" business: </span><br />
<span style="font-family: Arial, Helvetica, sans-serif;"><a href="http://sciencewatch.com/nobel/predictions/modular-click-chemistry" target="_blank">Thomson Reuters, </a></span><span style="font-family: Arial, Helvetica, sans-serif;"><a href="http://sciencewatch.com/nobel/predictions/modular-click-chemistry" target="_blank">Sciencewatch: Modular click chemistry</a> </span><br />
<span style="font-family: Arial, Helvetica, sans-serif;"><a href="http://voiceofrussia.com/2013_09_28/Goal-was-to-design-reaction-which-would-be-very-simple-to-use-for-non-specialis-Click-Chemistry-Nobel-Nominee-5571/" target="_blank">Radio "The voice of Russia": Complex reactions just a click away</a></span><br />
<span style="font-family: Arial, Helvetica, sans-serif;"><a href="http://www.utsandiego.com/news/2013/Sep/24/scripps-nobel-sharpless/" target="_blank">The San Diego Union - Tribune: Scripps chemist vies for second Nobel</a></span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">The field should contribute to something more significant in application, discovery of some drugs, some important materials, etc. </span><br />
<span style="font-family: Arial, Helvetica, sans-serif;">A ton of publications do not necessarily signify the chemistry. Needless to say, some publications do not really reflect the philosophy / spirit of click chemistry. </span><br />
<span style="font-family: Arial, Helvetica, sans-serif;">Fairly speaking, the field is too young for a Nobel Prize. Likely someday it will but no more predictions please. </span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">Let us focus on some really significant work. </span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;"> </span>Hongyi Wanghttp://www.blogger.com/profile/16501921836360298962noreply@blogger.com0tag:blogger.com,1999:blog-769130530453349168.post-11215856672181629082013-06-29T16:29:00.000-05:002013-06-29T16:29:04.129-05:00Chirality in drugs<span style="font-family: Arial, Helvetica, sans-serif;">“Asymmetric catalysis” won the Nobel chemistry prize in 2001 for Dr Knowles, Dr Noyori and Dr Sharpless. The pursuit of chiral drugs has been feverish for ever. Among resolution, separation, chiral synthesis, biocatalysis, etc. there is the effort of using enzyme to synthesize its own inhibitor. The Economist reported such an effort in the article "telling right from left", September 19, 2002, stated as following:</span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">Dr Sharpless goes even further. People are not very good at making medicines, he says. <span style="color: blue;">Life is short</span>, while conventional drug-discovery is a long and uncertain process. So why not put nature, which is much more patient and sophisticated at doing the job, to work directly? Just as a mould can be used to make a copy of a three-dimensional object, Dr Sharpless proposes to use biological targets as templates to guide the formation of their own perfect drugs. He calls the method <span style="color: lime;">“click chemistry</span>”, because of the ease with which the molecular building-blocks fit together. He and his colleagues have already used it in the laboratory to identify a molecule that blocks an enzyme related to Alzheimer's disease. Sometimes the best ideas are also the most obvious.</span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;"> </span>Hongyi Wanghttp://www.blogger.com/profile/16501921836360298962noreply@blogger.com0tag:blogger.com,1999:blog-769130530453349168.post-76264520110536829012013-04-28T14:23:00.000-05:002013-04-29T08:52:33.695-05:00Energetic / click chemistry and chemical industry<br />
<span style="font-family: Arial, Helvetica, sans-serif;">Energetic chemistry resides at the core of click chemistry concept. The energetic nature gives </span><span style="font-family: Arial, Helvetica, sans-serif;">high reactivity, short cycle times, clean reactions, less purification, therfore cost-saving. At the </span><span style="font-family: Arial, Helvetica, sans-serif;">same time energetic chemistry is highly underutilized due to the obvious concerns about the </span><span style="font-family: Arial, Helvetica, sans-serif;">very same energetic nature. It is particularly true in chemical industry and pharmaceutical industry. </span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">Things probably will change through a few means: demonstration of long-term success and safety by </span><span style="font-family: Arial, Helvetica, sans-serif;">the existing hazardous chemistry specialty companies; education and business development with </span><span style="font-family: Arial, Helvetica, sans-serif;">pharmaceutical companies; and most of all, competition pressure and overall cost-benefit calculation.</span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">Where and when the decision has to be made, it will be. As history often shows, changes happen under pressure not by forward thinking.</span><br />
Hongyi Wanghttp://www.blogger.com/profile/16501921836360298962noreply@blogger.com0tag:blogger.com,1999:blog-769130530453349168.post-2673938755788894492013-04-26T16:43:00.001-05:002013-04-26T16:43:34.839-05:00Novasep azide chemistry & click chemistry<br />
<span style="font-family: Arial, Helvetica, sans-serif;"><a href="http://www.novasep.com/" target="_blank">Novasep</a> has high expertise in azide chemistry, including several hundred ton annual usage </span><br />
<span style="font-family: Arial, Helvetica, sans-serif;">of sodium azide and large scale azide reactions. </span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">One example is the in-situ generation of explosive gas methylazide (N:C ratio 3:1) </span><span style="font-family: Arial, Helvetica, sans-serif;">for CuAAC click chemistry. </span><br />
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<a href="http://4.bp.blogspot.com/-C3CeWh1MUXo/UXr0dGe748I/AAAAAAAAAMY/bSvb4mYdiL8/s1600/Novasep+Azide+Click.bmp" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" height="56" src="http://4.bp.blogspot.com/-C3CeWh1MUXo/UXr0dGe748I/AAAAAAAAAMY/bSvb4mYdiL8/s400/Novasep+Azide+Click.bmp" width="400" /></a></div>
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Hongyi Wanghttp://www.blogger.com/profile/16501921836360298962noreply@blogger.com0tag:blogger.com,1999:blog-769130530453349168.post-32274781570931427052013-04-21T09:53:00.000-05:002013-04-26T16:44:04.723-05:00Phosphaalkyne azide click chemistry<br />
<span style="font-family: Arial, Helvetica, sans-serif;"><a href="http://pubs.rsc.org/en/content/articlelanding/2013/DT/C3DT50505G" target="_blank">Dalton Trans 2013, Choong et al</a> 3/21/13</span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">1,3-cycloaddition of </span><span style="font-family: Arial, Helvetica, sans-serif;">phosphaalkynes & azides to triazaphosphole</span><span style="font-family: Arial, Helvetica, sans-serif;">: </span><br />
<span style="font-family: Arial, Helvetica, sans-serif;">Uncatalyzed, </span><span style="font-family: Arial, Helvetica, sans-serif;">regioselective, quantitative or near-quantitative yield</span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">Near click chemistry except necessary protection of P(III) from oxidation. </span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">Triazaphospholes as </span><span style="font-family: Arial, Helvetica, sans-serif;">polydentate ligands in metalloorganic, dendrimer, polymer context </span><br />
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<a href="http://2.bp.blogspot.com/-6Rnfn5ZddkI/UXP8wT1HBwI/AAAAAAAAAMI/X8b64lCXPEU/s1600/CPClick3.bmp" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" height="396" src="http://2.bp.blogspot.com/-6Rnfn5ZddkI/UXP8wT1HBwI/AAAAAAAAAMI/X8b64lCXPEU/s400/CPClick3.bmp" width="400" /></a></div>
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Hongyi Wanghttp://www.blogger.com/profile/16501921836360298962noreply@blogger.com0tag:blogger.com,1999:blog-769130530453349168.post-82879064795491376812013-04-06T18:14:00.001-05:002013-04-21T13:42:49.473-05:00Human Cholesterol-binding proteins, a lot more<br />
<span style="font-family: Arial, Helvetica, sans-serif;">Hulce, Cognetta, Niphakis, Tully & Cravatt</span><br />
<span style="font-family: Arial, Helvetica, sans-serif;"><a href="http://www.nature.com/nmeth/journal/v10/n3/full/nmeth.2368.html" target="_blank">Nature Methods 2013, 10(3), 259</a></span><br />
<span style="font-family: Arial, Helvetica, sans-serif;">A lot more proteins bind to cholesterol than previously known.</span><br />
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Hongyi Wanghttp://www.blogger.com/profile/16501921836360298962noreply@blogger.com0tag:blogger.com,1999:blog-769130530453349168.post-22121606305156489072013-04-05T16:48:00.001-05:002013-04-05T16:48:28.507-05:00Triazole formation: substitution extreme cases<br />
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Hongyi Wanghttp://www.blogger.com/profile/16501921836360298962noreply@blogger.com0tag:blogger.com,1999:blog-769130530453349168.post-52778447797417531432013-03-31T10:18:00.002-05:002013-03-31T10:21:05.246-05:00Coupling biocatalysis and click chemistry<br />
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<span style="font-family: Arial, Helvetica, sans-serif;"><a href="http://pubs.rsc.org/en/content/articlelanding/2013/CC/C3CC38674K" target="_blank">Chem. Commun., 2013,49, 2625-2627</a></span></div>
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<span style="font-family: Arial, Helvetica, sans-serif;">DOI: 10.1039/C3CC38674K</span></div>
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<span style="font-family: Arial, Helvetica, sans-serif;">1,2,3-triazoles: pharmacophores and
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<span style="font-family: Arial, Helvetica, sans-serif;">Impressive driving force and selectivity.</span></div>
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Hongyi Wanghttp://www.blogger.com/profile/16501921836360298962noreply@blogger.com0tag:blogger.com,1999:blog-769130530453349168.post-37923882372272700682013-03-29T14:44:00.003-05:002013-03-29T14:46:49.841-05:00Azide chemistry, energetic chemistry, hazardous chemistry, click chemistry<br />
<span style="font-family: Arial, Helvetica, sans-serif;">The spring-loaded energetic chemicals, azides and acetylenes, provide the necessary driving force of the "ideal" and non-stoppable </span><span style="font-family: Arial, Helvetica, sans-serif;">triazole formation reaction, the most prominent of click chemistry concept. It is practiced in many academic groups worldwide, </span><span style="font-family: Arial, Helvetica, sans-serif;">maybe in some pharmaceutical, biotech companies as well. Azides are often used to introduce amino groups in organic </span><span style="font-family: Arial, Helvetica, sans-serif;">synthesis. Scanning any issue of JACS or JOC, one would see a bunch. </span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">In discovery chemistry where properties are sought, </span><span style="font-family: Arial, Helvetica, sans-serif;">azide chemistry is good, click chemistry is wonderful.</span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">When it comes to pharmaceutical or fine chemicals production, however, one tries to avoid azides as much as possbile, simply </span><span style="font-family: Arial, Helvetica, sans-serif;">due to the very energetic nature of it. Azides are hazardous, no question about it - particularly when it come to large scale production. </span><br />
<span style="font-family: Arial, Helvetica, sans-serif;">The avoidance however could add more steps of synthesis. Not good.</span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">Double edged sword. Something has to give? </span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">A few companies have had success with many hazardous chemistries, up to metric ton scale. This competence separates them </span><span style="font-family: Arial, Helvetica, sans-serif;">from competition. Extensive testing helps: impact & friction sensitivity, thermal stability, dust explosivity, reaction calorimetry. </span><span style="font-family: Arial, Helvetica, sans-serif;">Stepwise scale-up helps: from lab to kilolab to pilot to plant. Engineering with prevention and in-case scenario in mind helps. </span><span style="font-family: Arial, Helvetica, sans-serif;">Everyone's commitment and best training helps. Seamless work as a team helps. </span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">One day when a product by azide click chemistry is so successful and needs to be made by tons, it can be made. </span><br />
<span style="font-family: Arial, Helvetica, sans-serif;"> </span>Hongyi Wanghttp://www.blogger.com/profile/16501921836360298962noreply@blogger.com0tag:blogger.com,1999:blog-769130530453349168.post-46030246601886374392013-03-24T19:10:00.003-05:002013-03-24T19:10:53.647-05:00Craig Hawker receives ACS Award in Polymer Chemistry<span style="font-family: Arial, Helvetica, sans-serif;">Feburary 2013 </span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;"><a href="http://hawkergroup.mrl.ucsb.edu/craig-j-hawker" target="_blank">Hawker</a>, director of the Materials Research Laboratory at the University of California, Santa Barbara, has had an impact on the field of dendrimer chemistry, block copolymer, controlled free-radical polymerization - many of which are practical to be in commercial markets. </span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">He was one of the ground-breakers in convergent growth dendrimer synthesis. He was the first to introduce and apply click chemistry concept to dendrimer and material synthesis. See the <a href="http://onlinelibrary.wiley.com/doi/10.1002/anie.200454078/abstract" target="_blank">2004 key article</a> by Hawker Group and Sharpless Group. </span><br />
<br />Hongyi Wanghttp://www.blogger.com/profile/16501921836360298962noreply@blogger.com0tag:blogger.com,1999:blog-769130530453349168.post-46823154263307687812013-01-01T10:29:00.001-06:002013-01-01T10:31:09.596-06:00In situ click chemistry 10 years mark<span style="color: magenta; font-family: Arial, Helvetica, sans-serif;"><b>Happy New Year 2013</b></span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">C&EN did a brief piece "revisiting 2002" and took a look at in situ click chemistry. </span><span style="font-family: Arial, Helvetica, sans-serif;">Some key points:</span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">Original publication by Scripps Group in <a href="http://onlinelibrary.wiley.com/doi/10.1002/1521-3773(20020315)41:6%3C1053::AID-ANIE1053%3E3.0.CO;2-4/abstract" target="_blank">Angew Chem Int 2002, 1053</a> </span><br />
<span style="font-family: Arial, Helvetica, sans-serif;">Acetylcholinesterase directs the synthesis of its own potent inhibitor when induced-and-fit</span><br />
<span style="font-family: Arial, Helvetica, sans-serif;">Difficulties: large quantity of protein, little quantity of inhibitor, slow reaction, etc</span><br />
<span style="font-family: Arial, Helvetica, sans-serif;">Ten years have seem a few successes but limited adoption</span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">Copper catalyzed version (CuAAC) enjoyed widespread popularity</span><br />
<span style="font-family: Arial, Helvetica, sans-serif;">Original publication by the Group in<a href="http://onlinelibrary.wiley.com/doi/10.1002/1521-3773(20020715)41:14%3C2596::AID-ANIE2596%3E3.0.CO;2-4/abstract" target="_blank"> Angew Chem Int 2002, 2596</a></span><br />
<span style="font-family: Arial, Helvetica, sans-serif;">Forget Not the Key ---- <span style="background-color: white;"> </span></span><br />
<span style="font-family: Arial, Helvetica, sans-serif;"><span style="background-color: white;"><span style="color: magenta;"><b>Fast "molecular discovery" for functions</b></span></span> </span><br />
<span style="font-family: Arial, Helvetica, sans-serif;"> </span>Hongyi Wanghttp://www.blogger.com/profile/16501921836360298962noreply@blogger.com0tag:blogger.com,1999:blog-769130530453349168.post-72922814395161495822012-12-19T12:05:00.001-06:002012-12-19T12:09:24.102-06:00LI-COR offers click chemistry reagents / dyes<br />
<span style="font-family: Arial, Helvetica, sans-serif;">Li-Cor, the company of "environmental and biotechnology research systems", </span><span style="font-family: Arial, Helvetica, sans-serif;">started to </span><a href="http://www.licor.com/bio/products/reagents/click_chemistry/clickChemistryOverview.jsp" style="font-family: Arial, Helvetica, sans-serif;" target="_blank">offer click chemistry reagents</a><span style="font-family: Arial, Helvetica, sans-serif;">. </span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">They combined click chemistry with its unique long-wavelength Infrared dyes. </span><span style="font-family: Arial, Helvetica, sans-serif;">Dyes include: IRDye 800CW, TRDye 680RD, IRDye 650. </span><span style="font-family: Arial, Helvetica, sans-serif;">Click chemistry gourps include: dibenzocyclooctyne (DBCO), azide and alkyne. </span><span style="font-family: Arial, Helvetica, sans-serif;">The coupling of above (3x3) generated 9 reagents - for click chemistry in the<a href="http://www.licor.com/bio/news/12.11.12.jsp" target="_blank"> field of in vitro</a> </span><a href="http://www.licor.com/bio/news/12.11.12.jsp" style="font-family: Arial, Helvetica, sans-serif;" target="_blank">or in vivo labeling and tracking of biomolecules.</a><span style="font-family: Arial, Helvetica, sans-serif;"> </span><span style="font-family: Arial, Helvetica, sans-serif;">Options are available with copper-catalyzed and copper-free versions of click chemistry. </span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">A </span><a href="http://www.licor.com/bio/educational_resources/webinars_videos/videos/odyssey/click_chemistry/click_chemistry_webinar.jsp" style="font-family: Arial, Helvetica, sans-serif;" target="_blank">webinar</a><span style="font-family: Arial, Helvetica, sans-serif;"> is provided for viewers.</span><br />
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Hongyi Wanghttp://www.blogger.com/profile/16501921836360298962noreply@blogger.com0tag:blogger.com,1999:blog-769130530453349168.post-83784999494498114042012-12-16T11:04:00.000-06:002012-12-16T11:05:41.856-06:00Nicholas Turro and the legacy<span style="font-family: Arial, Helvetica, sans-serif;"><a href="http://turroserver.chem.columbia.edu/" target="_blank">Nicholas Turro</a> died on November 24, 2012. </span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">Many of us learned from his photochemistry book, watched his photochemistry videos, met him in person, listened to his presentation on supramolecular photochemistry, and read his recent work on the applications of click chemistry. </span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">Dr Turro is a truly classy figure in many ways: on</span><span style="font-family: Arial, Helvetica, sans-serif;">e of the giants of modern photochemistry; leader and trail-blazer of creative research in new fields; excellent teacher, educator and lecturer to many levels; superb book writer and natural presenter; father of the large "Turro" academic family; member of NAS and AAAS; recipient of many elite awards. </span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">A big loss and many will miss him. </span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;"> </span>Hongyi Wanghttp://www.blogger.com/profile/16501921836360298962noreply@blogger.com0tag:blogger.com,1999:blog-769130530453349168.post-70060728123127585122012-12-16T10:31:00.000-06:002012-12-16T10:31:33.871-06:00Click chemistry in single molecule sequencing <div class="separator" style="clear: both; text-align: left;">
<span style="font-family: Arial, Helvetica, sans-serif;">Well, click chemistry has come to single molecule sequencing, one of the hottest spots in modern biotechnology. Pacific Biosciences has demonstrated the sensitive and specific single molecule sequencing of 5-hydroxylmethylcytosine in DNA. Here it is summarized:</span></div>
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<a href="http://www.nature.com/nmeth/journal/v9/n1/full/nmeth.1779.html" style="font-family: Arial, Helvetica, sans-serif;" target="_blank">Nature Methods, 2012, 9(1), 75</a><br />
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Hongyi Wanghttp://www.blogger.com/profile/16501921836360298962noreply@blogger.com0tag:blogger.com,1999:blog-769130530453349168.post-38203212017259027122012-11-21T08:34:00.000-06:002012-11-21T08:38:28.746-06:00Click chemistry in solving protein 3-D structures<span style="font-family: Arial, Helvetica, sans-serif;">Long live protein chemistry! Early days saw the use of cross-linking reagents such as DCC to lock in spatially adjacent amino groups within proteins. Nowadays the progress of mass spectrometry and proteomics has greatly enhanced the ability to study protein 3-D structures and protein interactions. Here a group of researchers went to click chemistry for additional assistance. <a href="http://pubs.acs.org/doi/abs/10.1021/ac202637n" target="_blank">Anal Chem 2012, 2662</a></span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">See the scheme:</span><br />
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<a href="http://3.bp.blogspot.com/-w1oOUn0WWlE/UKzl6P64hmI/AAAAAAAAAKY/fENEr5oW0p4/s1600/Protein3D.bmp" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" src="http://3.bp.blogspot.com/-w1oOUn0WWlE/UKzl6P64hmI/AAAAAAAAAKY/fENEr5oW0p4/s1600/Protein3D.bmp" /></a></div>
Hongyi Wanghttp://www.blogger.com/profile/16501921836360298962noreply@blogger.com0tag:blogger.com,1999:blog-769130530453349168.post-46751368274379482112012-11-11T11:16:00.004-06:002012-11-11T11:16:49.492-06:00Versita plans ambitious Click Chemistry Publication<br />
<span style="font-family: Arial, Helvetica, sans-serif;">"Versita, Emerging Science Publishers", has planned an <a href="http://versita.com/cch/" target="_blank">electronic journal for click chemistry</a>. </span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">In its statement, it intends to be :</span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">1. the first, main option, central and most authoritative publication in click chemistry</span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">2. a new hub, new forum and breeding ground for collaborations between disciplines united by the philosophy of click chemistry </span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">Journal Editor Dominic V. McGrath, Universityof Arizona, USA</span><br />
<span style="font-family: Arial, Helvetica, sans-serif;">ISSN: 2299-3932 (electronic version); </span><br />
<span style="font-family: Arial, Helvetica, sans-serif;">Owner: Versita, Warsaw, Poland</span><br />
<span style="font-family: Arial, Helvetica, sans-serif;">Publisher: Versita, Warsaw, Poland</span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">Ambitious yet challenging, since there exist similar virtual publication channels already. </span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">Good luck!</span><br />
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Hongyi Wanghttp://www.blogger.com/profile/16501921836360298962noreply@blogger.com0tag:blogger.com,1999:blog-769130530453349168.post-28629346993110275852012-11-10T10:04:00.001-06:002012-11-10T10:06:59.280-06:00Click chemistry, condensed<span style="font-family: Arial, Helvetica, sans-serif;">We like short meetings, short waiting lines, fast foods, right? How about a new 3-page description of the status of click chemistry? Highly recommend this article.</span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">R&D, 10/10/2012, Thundimadathil, <a href="http://www.rdmag.com/articles/2012/10/new-reactions-click-chemistry" target="_blank">"</a></span><span style="font-family: Arial, Helvetica, sans-serif;"><a href="http://www.rdmag.com/articles/2012/10/new-reactions-click-chemistry" target="_blank">New reactions with click chemistry: simple and elegant chemical reactions have far-reaching applications in R&D"</a></span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">This short account covers the most significant key information on click chemistry, in a extremely condensed manner. Lots of admiration for the author's ability to deliver so much info in so little space. </span><br />
<a href="http://4.bp.blogspot.com/--WVw4o_R7ls/UJ50eECm7sI/AAAAAAAAAKA/v46UeVL25w8/s1600/ClickChemFig2x250.jpg" imageanchor="1" style="clear: left; display: inline !important; margin-bottom: 1em; margin-right: 1em; text-align: center;"><img border="0" height="400" src="http://4.bp.blogspot.com/--WVw4o_R7ls/UJ50eECm7sI/AAAAAAAAAKA/v46UeVL25w8/s400/ClickChemFig2x250.jpg" width="400" /></a><br />
<span style="font-family: Arial, Helvetica, sans-serif;">Best of all - how wonderful is this: "Due to the simplicity of click reactions, <span style="background-color: white;">biochemists and molecular biologists</span> are able to make complex molecular systems <span style="color: red;">without much bothering about the synthetic chemistry</span>. Click chemistry is approaching the level of <span style="color: red;">ready-made chemistry </span>as many kits are already available in the market for an easy <span style="color: red;">mix and shake</span> approach" </span><br />
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Hongyi Wanghttp://www.blogger.com/profile/16501921836360298962noreply@blogger.com0tag:blogger.com,1999:blog-769130530453349168.post-27415242771758582902012-10-14T16:28:00.003-05:002012-10-14T16:31:04.586-05:00Enamine click chemistry libraries: Azides and terminal acetylenes<span style="font-family: Arial, Helvetica, sans-serif;"><br /></span>
<span style="font-family: Arial, Helvetica, sans-serif;"><a href="http://www.enamine.net/index.php" target="_blank">Enamine</a> claims to be the "World largest collection </span><span style="font-family: Arial, Helvetica, sans-serif;">of tangible building blocks </span><span style="font-family: Arial, Helvetica, sans-serif;">and fragments for drug discovery". </span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">Related to click chemistry, the numbers of tangible structures for azides and terminal acetylenes are 3100 and 9200, respectively. These are estimated to be reliably and quickly synthesized as libraries.</span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">A large existing library of <a href="http://www.enamine.net/index.php?option=com_content&task=view&id=127" target="_blank">Azides for click chemistry</a> is available and has been used by researchers and companies alike. </span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">One could use acetylene libraries for screening of candidates. The selected ones could be reacted with azides libraries to create a pool for further screening. </span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">In other applications one may modify the molecule of interest with one of the above two functional groups and subject it to the other FG libraries for creating a library for further screening or property improvement.</span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;"> </span>Hongyi Wanghttp://www.blogger.com/profile/16501921836360298962noreply@blogger.com0tag:blogger.com,1999:blog-769130530453349168.post-21550820748792113372012-07-28T14:17:00.001-05:002012-10-14T16:32:50.814-05:00Sharpless click chemistry talk at Nobel Campus<span style="font-family: Arial, Helvetica, sans-serif;"><br /><br />July 1-4, 2012. <a href="http://www.ceics.eu/nobel-campus/index.html" target="_blank">“Southern Catalonia Nobel Campus”</a> was held at The Campus of International Excellence Southern Catalonia, Spain. <br /><br />“Chemistry for Life”, one hundred young researchers have been chosen in this unique experience to interact with the <a href="http://vimeo.com/channels/357270" target="_blank">6 Nobel laureates</a>: Sidney Altman, Ryoji Noyori, Barry Sharpless, Aaron Ciechanover, Richard R. Schrock and Ada E. Yonath. Also there were the leaders and scientists from industrial world.<br /><br />A <a href="http://vimeo.com/45116622" target="_blank">talk by Barry Sharpless</a> covers many topics including click chemistry. Many seemingly random and scattered thoughts may better be heart-felt when one has gained quite some experience into the research career. Say, illusions, astronomical number of possible compounds, function, fishing, on-water reactions, German chemistry tradition, the huge wealth of chemistry in place today, Invitrogen Click-It, etc. </span><br />
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Hongyi Wanghttp://www.blogger.com/profile/16501921836360298962noreply@blogger.com0tag:blogger.com,1999:blog-769130530453349168.post-34198551614341943552012-07-06T14:45:00.002-05:002012-07-06T14:46:49.265-05:00Bertozzi: bioorthogonal & click chemistry out of curiosity<span style="font-family: Arial, Helvetica, sans-serif;">A sum-up <a href="http://www.kavlifoundation.org/kavli-news/ACS-Bertozzi-bioorthogonal-chemistry" target="_blank">Lecture on bioorthogonal chemistry by Bertozzi@ Kavli Foundation</a> during ACS Spring 2012 National Meeting in San Diego on March 26, 2012. <br /><br /><a href="http://vimeo.com/37670905">"Bioorthogonal chemistry is literally chemistry for life"</a> <br /><br />Bioorthogonal chemistry and click chemistry owe the debt to the curiosity-driven rather than problem-driven discoveries by two German scientists, Hermann Staudinger & Rolf Huisgen, nearly a century ago. "Without some curiosity-driven research we won't leave much of a legacy for the next generation of scientists".<br /><br />Bertozzie coined bioorthogonal chemistry decade ago to probe "biomolecules within their native habitats, that is, in cells, or even better, live organisms". The group developed first bioorthogonal reaction, Staudinger ligation, slow for most biological processes. Sharpless CuACC is 25 times faster than Staudinger but with copper toxicity. Copper-free click chemistry, DIFO, combines biocompatibility of Staudinger ligation with fast kinetics of triazol click chemistry. </span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;"> </span></div>Hongyi Wanghttp://www.blogger.com/profile/16501921836360298962noreply@blogger.com0tag:blogger.com,1999:blog-769130530453349168.post-7964821976389568382012-07-06T05:55:00.001-05:002012-07-06T05:55:41.185-05:00Stability & reactivity, copper-free click chemistry<a href="http://pubs.acs.org/doi/pdf/10.1021/ja3000936" target="_blank"><span style="font-family: Arial, Helvetica, sans-serif;">JACS 2012, Angew. Chem. Int. Ed. 2012, 51, 2443</span></a><br />
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<span style="background-color: white; font-family: Arial, Helvetica, sans-serif;">A contribution from Bertozzi group, on the stability and reactivity of cycloalkynes </span><br />
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<a href="http://3.bp.blogspot.com/-UKmsWu1OeM4/T_bBJaWkcQI/AAAAAAAAAJQ/koEE9Ex8iV8/s1600/Cycloalkynes.bmp" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" height="400" src="http://3.bp.blogspot.com/-UKmsWu1OeM4/T_bBJaWkcQI/AAAAAAAAAJQ/koEE9Ex8iV8/s400/Cycloalkynes.bmp" width="351" /></a></div>
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<span style="font-family: Arial, Helvetica, sans-serif;">Bioorthogaonal chemistry: stable while fast reacting in highly functionalized environment</span><br />
<span style="background-color: white; font-family: Arial, Helvetica, sans-serif;">Rapid reaction kinetics, high specificity, good stability, low side-reactivity</span><br />
<span style="background-color: white; font-family: Arial, Helvetica, sans-serif;">activating vs deactivatiing modifications: ring size (relaxing or strain), electronic factors </span><br />
<span style="font-family: Arial, Helvetica, sans-serif;">(electron with-drawing, hybridization patterns), stabilizing large atoms as sulfur / Silicon etc.</span><br />
<span style="background-color: white; font-family: Arial, Helvetica, sans-serif;">Cu-free click chemistry, cycloaddition between azides and cyclooctynes</span><br />
<span style="background-color: white; font-family: Arial, Helvetica, sans-serif;">Stability and reactivity can be fine-tuned </span><br />
<span style="background-color: white; font-family: Arial, Helvetica, sans-serif;"> </span><br />Hongyi Wanghttp://www.blogger.com/profile/16501921836360298962noreply@blogger.com0tag:blogger.com,1999:blog-769130530453349168.post-61674067773194210822012-06-27T16:36:00.000-05:002012-06-27T16:36:27.651-05:00Click chemistry on hair 2<div class="separator" style="clear: both; text-align: left;">
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<span style="font-family: Arial, Helvetica, sans-serif;">Here is the click chemistry to be applied in the salons :))</span><br />
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<a href="http://1.bp.blogspot.com/--YTO7JMLhCg/T-t8mvgRyfI/AAAAAAAAAI8/y4ekr0TsoRU/s1600/hairclick.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="640" src="http://1.bp.blogspot.com/--YTO7JMLhCg/T-t8mvgRyfI/AAAAAAAAAI8/y4ekr0TsoRU/s640/hairclick.jpg" width="272" /></a></div>Hongyi Wanghttp://www.blogger.com/profile/16501921836360298962noreply@blogger.com0tag:blogger.com,1999:blog-769130530453349168.post-24233704982263644522012-06-25T13:20:00.003-05:002012-06-25T13:20:52.047-05:00Click chemistry on hair 1<br />
<a href="http://pubs.rsc.org/en/content/articlelanding/2012/py/c2py20040f" target="_blank"><span style="font-family: Arial, Helvetica, sans-serif;">Poly. Chem. 2012, 3, 1461</span></a><br />
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<span style="background-color: white;"><span style="font-family: Arial, Helvetica, sans-serif;">Finally, click chemistry goes to cosmetic industry, the fastest-growing industry of all? </span></span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">Well, sure thing is that you do need fast, mild, high-yielding, failure-proof, safe reactions </span><br />
<span style="font-family: Arial, Helvetica, sans-serif;">to be happening in hair salons (on the head). Doe that sound like a "perfect" reaction, in the spirit of click chemistry?</span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">Here comes an interesting one applying two types of thiol-ene click chemistry on hair.</span><br />
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<span style="font-family: Arial, Helvetica, sans-serif;">1. Polymerisation of mixed acrylates produced the polymer with acrylate terminal alkene </span><br />
<span style="font-family: Arial, Helvetica, sans-serif;">and allyl internal alkenes </span><br />
<span style="font-family: Arial, Helvetica, sans-serif;">2. Thiol-ene click chemistry produced conjugates between polymer terminal alkene and thiol </span><br />
<span style="font-family: Arial, Helvetica, sans-serif;">groups exposed from hair alpha-keratin</span><br />
<span style="font-family: Arial, Helvetica, sans-serif;">3. Thiol-ene click chemistry produced modification between polymer internal alkene and thiol </span><br />
<span style="font-family: Arial, Helvetica, sans-serif;">groups from dye ------- or any other fun stuff.</span><br />
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<br /></div>Hongyi Wanghttp://www.blogger.com/profile/16501921836360298962noreply@blogger.com0tag:blogger.com,1999:blog-769130530453349168.post-66715540046987974482012-06-03T21:09:00.001-05:002012-06-03T21:09:47.093-05:00Branched Y-Shaped DNA by Click Chemistry<br />
<span style="font-family: Arial, Helvetica, sans-serif;"><a href="http://pubs.acs.org/doi/abs/10.1021/bc300013k" target="_blank">Bioconjugate Chem., 2012, 23 (4), pp 856–870</a></span><br />
<span style="font-family: Arial, Helvetica, sans-serif;">DOI: 10.1021/bc300013k</span><br />
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<a href="http://3.bp.blogspot.com/-LF6XHa7iYzU/T8wYM0SwTlI/AAAAAAAAAIA/U3Oolu635HA/s1600/Y+shape.bmp" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" height="297" src="http://3.bp.blogspot.com/-LF6XHa7iYzU/T8wYM0SwTlI/AAAAAAAAAIA/U3Oolu635HA/s400/Y+shape.bmp" width="400" /></a></div>
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<span style="font-family: Arial, Helvetica, sans-serif;">Stepwise and double click chemistry produced branched Y-shaped three-armed DNA. </span><br />
<span style="font-family: Arial, Helvetica, sans-serif;">Hybridization of branched DNA with complementary oligonucleotides yielded </span><span style="font-family: Arial, Helvetica, sans-serif;">supramolecular assemblies / nanostructures.</span><br />Hongyi Wanghttp://www.blogger.com/profile/16501921836360298962noreply@blogger.com0