Saturday, December 10, 2011

Click chemistry a click away

This is to respond to a reader's excellent request - why not put together a list of vendors of click chemistry reagents, with active links, to make click chemistry a click away? Here it goes:

http://www.sigmaaldrich.com/chemistry/chemical-synthesis/technology-spotlights/click.html


http://www.invitrogen.com/site/us/en/home/Products-and-Services/Applications/Cell-Analysis/Labeling-Chemistry/Click-chemistry-Labeling-and-Detection.html

http://www.lumiprobe.com/c/click-chemistry-reagents


http://www.clickchemistrytools.com/Products.html

http://www.creativepegworks.com/Click_PEG_derivatives.html

http://www.activemotif.com/catalog/681/fluorescent-tools-for-click-chemistry

http://www.jenabioscience.com/cms/en/1/browse/1379_click_chemistry_reagents.html

http://www.idtdna.com/pages/decoded/decoded-articles/find-out-first-2/decoded/2011/09/12/click-chemistry

http://www.iba-go.com/naps/naps_p_edcc.html

http://www.enamine.net/index.php?option=com_content&task=view&id=127

http://www.berryassoc.com/clickmates.asp

http://www.glenresearch.com/GlenReports/GR23-13.html

http://www.anaspec.com/products/promotions.asp?id=55&col=2&row=2

http://www.quantabiodesign.com//

http://www.primetech.by/en/biocon_click.html

http://www.gfschemicals.com/statics/documents/randd/randd2a82dd80b59a4d08a177471f6aadf1a6.html

http://www.baseclick.eu/products.php

http://www.setabiomedicals.com/click-chemistry.php

http://www.interchim.fr/ft/F/FY2780.pdf

http://www.amtechpl.com/docs/AMT%20Click%20Chemistry%20Fact%20Sheet_V1%200_20111129.pdf

http://www.chemgenes.com/products.php

http://www.iris-biotech.de/pegylation/peg-azides-for-click-chemistry.html

http://www.piercenet.com/browse.cfm?fldID=78C8CEF4-5056-8A76-4E62-B899CF83E209

http://www.caymanchem.com/app/template/productQualifiers%2CProductQualifier.vm/productqualifier/click-chemistry

http://www.cambio.co.uk/1160/66/products/azide-tags/

http://www.fluorous.com/groups/174-10.html

http://www.metabion.com/products/click.php

http://www.bachem.com/newsletter/July_2011_New_Products.html

http://pepnet.com/shoppingusers/PdfDocument.aspx?FileName=pepnet242.pdf

http://www.cyanine.com/life-science/applications/click-chemistry

http://www.prochimia.com/compound_description.php?prod_id=8

http://proteinslides.com/click.html

A few notes:
1. No way it is exclusive - please let me know the ones I have missed so I can add them in future updates.
2. Chances are the addresses would change over time - the best way then is to copy the company link to your web browser and click to get to the vendor followed by search that website. 
3. It was stated why "vendors matter" in a separate post.

Sunday, December 4, 2011

Diels-Alder Click Chemistry for Tissue Engineering Hydrogel

Biomacromolecules, 2011, 12 (3), pp 824–830



Diels-Alder cycloaddition satisfies click chemistry criteria and features elegant multiple-bond formation in a single step in very high yeild. Here a furan diene was installed onto the natural polymer hyaluronic acid and it was cross-linked by a bifunctional dienophile, dimaleimide poly(ethylene glycol) to form the cytocompatible hydrogels for potential soft tissue engineering. The click reaction runs smoothly in aqueous buffer without initiator, catalyst, or other coupling reagents.