Feburary 2013
Hawker, director of the Materials Research Laboratory at the University of California, Santa Barbara, has had an impact on the field of dendrimer chemistry, block copolymer, controlled free-radical polymerization - many of which are practical to be in commercial markets.
He was one of the ground-breakers in convergent growth dendrimer synthesis. He was the first to introduce and apply click chemistry concept to dendrimer and material synthesis. See the 2004 key article by Hawker Group and Sharpless Group.
Sunday, March 24, 2013
Tuesday, January 1, 2013
In situ click chemistry 10 years mark
Happy New Year 2013
C&EN did a brief piece "revisiting 2002" and took a look at in situ click chemistry. Some key points:
Original publication by Scripps Group in Angew Chem Int 2002, 1053
Acetylcholinesterase directs the synthesis of its own potent inhibitor when induced-and-fit
Difficulties: large quantity of protein, little quantity of inhibitor, slow reaction, etc
Ten years have seem a few successes but limited adoption
Copper catalyzed version (CuAAC) enjoyed widespread popularity
Original publication by the Group in Angew Chem Int 2002, 2596
Forget Not the Key ----
Fast "molecular discovery" for functions
C&EN did a brief piece "revisiting 2002" and took a look at in situ click chemistry. Some key points:
Original publication by Scripps Group in Angew Chem Int 2002, 1053
Acetylcholinesterase directs the synthesis of its own potent inhibitor when induced-and-fit
Difficulties: large quantity of protein, little quantity of inhibitor, slow reaction, etc
Ten years have seem a few successes but limited adoption
Copper catalyzed version (CuAAC) enjoyed widespread popularity
Original publication by the Group in Angew Chem Int 2002, 2596
Forget Not the Key ----
Fast "molecular discovery" for functions
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