Thiol-yne click chemistry

Sounds familiar? "A perusal of the literature from 1940s to 1960s" prompted this new version of click chemistry.

As indicated in the scheme, the double thiol-addition happens in two consecutive steps with the second 3-times faster than the first. The reaction can be driven either by light or radical initiators. Not only it complements established click chemistries such as alkyne-azide and thiol-ene, but also it provides a new feature which enables installation of more functional groups at once. This click chemistry was demonstrated with a few recent examples, either individually or in combination with other click chemitries. It is best suited for construction of dendrimers, networked structures, polymers, and other functional materials. I would expect it to find applications in biotechnology, nanotechnology, surface chemistry,  etc. 

Andrew B. Lowe et al, J. Mater. Chem., 2010, DOI: 10.1039/b917102a