Click chemistry in solving protein 3-D structures

Long live protein chemistry! Early days saw the use of cross-linking reagents such as DCC to lock in spatially adjacent amino groups within proteins. Nowadays the progress of mass spectrometry and proteomics has greatly enhanced the ability to study protein 3-D structures and protein interactions. Here a group of researchers went to click chemistry for additional assistance. Anal Chem 2012, 2662

See the scheme: