Energetic / click chemistry and chemical industry

Energetic chemistry resides at the core of click chemistry concept. The energetic nature gives high reactivity, short cycle times, clean reactions, less purification, therfore cost-saving. At the same time energetic chemistry is highly underutilized due to the obvious concerns about the very same energetic nature. It is particularly true in chemical industry and pharmaceutical industry. 

Things probably will change through a few means: demonstration of long-term success and safety by the existing hazardous chemistry specialty companies; education and business development with pharmaceutical companies; and most of all, competition pressure and overall cost-benefit calculation.

Where and when the decision has to be made, it will be. As history often shows, changes happen under pressure not by forward thinking.
               

Novasep azide chemistry & click chemistry

Novasep has high expertise in azide chemistry, including several hundred ton annual usage 
of sodium azide and large scale azide reactions. 

One example is the in-situ generation of explosive gas methylazide (N:C ratio 3:1) for CuAAC click chemistry. 

Phosphaalkyne azide click chemistry

Dalton Trans 2013, Choong et al   3/21/13

1,3-cycloaddition of phosphaalkynes & azides to triazaphosphole: 
Uncatalyzed, regioselective, quantitative or near-quantitative yield

Near click chemistry except necessary protection of P(III) from oxidation. 

Triazaphospholes as polydentate ligands in metalloorganic, dendrimer, polymer context 

                     

Human Cholesterol-binding proteins, a lot more

Hulce, Cognetta, Niphakis, Tully & Cravatt
Nature Methods 2013, 10(3), 259
A lot more proteins bind to cholesterol than previously known.

Triazole formation: substitution extreme cases