Saturday, October 29, 2011

Ten years of click chemistry summed up

Two recent special issues were dedicated to click chemistry and bioorthogonal chemistry.

1. Chemistry – An Asian Journal, Volume 6, Issue 10, Pages 2565–2847Special Issue: Celebrating the 10th Anniversary of Click Chemistry

October 4, 2011
Guest Editors: Qian Wang, Craig Hawker

2. Accounts of Chemical Research, Volume 44, Issue 9, Pages 651-840Special Issue: A decade of Bioorthogonal Chemistry
September 20, 2011
Guest Editor: Carolyn Bertozzi

Achievements of a decade were summed up and documented in 470-plus pages by active researchers in the field. Editors gave historical perspective as well.

Excellent resources! 

Sunday, October 2, 2011

Triazole in polymer under attack by ultrasound 2

A little more work on this topic and two additions:

First, as indicated in the graph, polymer solutions are degraded by ultrasound in a controlled manner. Timothy Mason, Sonochemistry, p 18. 

Second, forward triazole formation, one of the click chemistry examples, was reported to be accelerated by ultrasound, in small molecule context. See the 2011 article and cited ones.
Giancarlo Cravotto et al, "Power ultrasound in metal-assisted synthesis: From classical Barbier-like reactions to click chemistry"
Ultrasonics Sonochemistry Volume 18, Issue 4, July 2011, Pages 836-841