Sunday, April 28, 2013
Energetic chemistry resides at the core of click chemistry concept. The energetic nature gives high reactivity, short cycle times, clean reactions, less purification, therfore cost-saving. At the same time energetic chemistry is highly underutilized due to the obvious concerns about the very same energetic nature. It is particularly true in chemical industry and pharmaceutical industry.
Things probably will change through a few means: demonstration of long-term success and safety by the existing hazardous chemistry specialty companies; education and business development with pharmaceutical companies; and most of all, competition pressure and overall cost-benefit calculation.
Where and when the decision has to be made, it will be. As history often shows, changes happen under pressure not by forward thinking.
Friday, April 26, 2013
Novasep has high expertise in azide chemistry, including several hundred ton annual usage
of sodium azide and large scale azide reactions.
One example is the in-situ generation of explosive gas methylazide (N:C ratio 3:1) for CuAAC click chemistry.
Sunday, April 21, 2013
Dalton Trans 2013, Choong et al 3/21/13
1,3-cycloaddition of phosphaalkynes & azides to triazaphosphole:
Uncatalyzed, regioselective, quantitative or near-quantitative yield
Near click chemistry except necessary protection of P(III) from oxidation.
Triazaphospholes as polydentate ligands in metalloorganic, dendrimer, polymer context