Diels-Alder cycloaddition satisfies click chemistry criteria and features elegant multiple-bond formation in a single step in very high yeild. Here a furan diene was installed onto the natural polymer hyaluronic acid and it was cross-linked by a bifunctional dienophile, dimaleimide poly(ethylene glycol) to form the cytocompatible hydrogels for potential soft tissue engineering. The click reaction runs smoothly in aqueous buffer without initiator, catalyst, or other coupling reagents.
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