Large Stokes Shift Dyes for Click Chemistry Applications

Large Stokes Shift Dyes feature a large separation between absorption and emission and allow unique advantages for  multiplexing, FRET and other applications. This is to summarize a few large Stokes shift dyes from recent literature and vendors, including several large Stokes shift dyes carried by Sigma-Aldrich for click chemistry applications. Synthetic or natural polymers and nano particles are not included.

Oligosaccharide Cellulose Membrane by click chemistry for Virus Adsorption

Previously Hatanaka and coworkers demonstrated that production of oligosaccharides (sialyl lactoside derivatives) was achieved by using saccharide primers (azidododecyl beta-lactosides) and B16 cells. 

Chemistry & Biodiversity, 2005, 1063.


Now they have used click chemistry to modify carboxymethylated cellulose (CMC) with terminal alkyne functional groups and introduced oligosaccharide via triazole clcik chemistry. The membrane was shown to have adsorption ability of influenza virus. The click chemistry is shown in the drawing.

The Open Chemical and Biomedical Methods Journal 2009, 13.