Saturday, March 20, 2010

Click chemistry highlighted in Chemical Society Reviews Special Issue

Chem. Soc. Rev., 2010, DOI: 10.1039/c003740k

I would say it is a feast - a colletion of the most representative pieces of click chemistry. It  is certainly a must-read for both active practitioners and the ones who are looking to step in.  

Edited by Drs Finn and Fokin and writen by leading groups, this special issue highlights the most recent status of click chemistry and its applications in several major fields. By doing so it effectively reinforces the importance of click chemistry concept. 

The three fields are covered: biomolecules, materials, and different environments. In each of them click chemistry has been demonstrated to be a powerful and growing tool. As the editors pointed out (again): "the more tolerant the connection reaction between molecular building blocks, the more diverse the blocks that can be brought to bear on any problem, and the more likely it will be that solutions to the problem can be found and produced in quantity. If indeed it is useful function that is the goal, then keeping chemistry simple is a useful rule to remember."

"In this deliberate eschewing of more subtle synthetic techniques is an implicit challenge to organic chemists that make complex structures by complex methods (can complex structures be made by simple methods?)......." Quite a challenge to say the least.

Click chemistry: function follows form.   

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