Monday, March 1, 2010

Click chemistry patent - cyclopeptide imaging agents

US 7666392 B2

A good example of the application of click chemistry in biomedicine and diagnostics.

This patent by Hartmuth Kolb et al, was issued on February 23, 2010.
The title reads as "Click chemistry derived cyclopeptide derivatives as imaging agents for integrins". It described radiolabeled cyclic peptides and their use in imaging, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomagraphy (SPECT). The graph shows one example where two units of cyclic peptides, via a PEG linker, are conjugated to the radiolabel by triazole click chemistry. It is obviously advantageous to introduce the radiolabels by the "near-perfect" click chemistry.

Note Dr. Kolb is one of the authors of the influential article "Diverse Chemical Function from a Few Good Reactions".
Kolb, Finn, Sharpless, Angew. Chem. Int. Ed. 2001, 40(11), 2004

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