Sunday, February 5, 2012

Nanoparticle heteroconjugation via click chemistry

ACS Nano 2012, 6(1) 310  describes nanoparticle heteroconjunction, summarized in the following graph: 

A few key points:
1. Conjugation of Nanoparticle is less reported
2. Many factors against NP conjugation: large size, slow movement, fewer functional groups, lower effective FG concentration, etc
3. A kinetically "unstoppable" reaction is required, such as CuAAC click chemistry
4. Vast possibilities in terms of varieties and functionalities from NP heteroconjugation
5. Controls validated the click chemistry 
6. Will Cu1+ and Cu2+ be an issue in similar applications? 

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