Org. Biomol. Chem. 2011, 9, 5373 Selectin of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain
Click chemistry was applied to create neoglycoconjugates from deoxynojirimycin and adamantane, These were bioassayed against a few enzymes as inhibitors or agonist.
These molecules featured both very hydrophilic and hydrophobic end groups, joined by triazole groups giving spacers / linkers with different lengths. These allow some specificity in terms of different targeted proteins.