A contribution from Bertozzi group, on the stability and reactivity of cycloalkynes
Bioorthogaonal chemistry: stable while fast reacting in highly functionalized environment
Rapid reaction kinetics, high specificity, good stability, low side-reactivity
activating vs deactivatiing modifications: ring size (relaxing or strain), electronic factors
(electron with-drawing, hybridization patterns), stabilizing large atoms as sulfur / Silicon etc.
Cu-free click chemistry, cycloaddition between azides and cyclooctynes
Stability and reactivity can be fine-tuned